Course Description

Liver biopsy interpretation is challenging because many liver diseases manifest overlapping histological features. A systematic pattern-based approach facilitates identification of subtle features that help to narrow the differential diagnoses, correlate findings with clinical data and provide a meaningful report. This course includes the full spectrum of neoplastic and non-neoplastic liver pathology; teaching modules include hepatitic, biliary, lobular, vascular and near-normal patterns of liver injury, hepatocellular neoplasms, biliary and mesenchymal tumors and transplant pathology. An interactive microscopy approach allows independent examination of a set of glass slides followed by discussion around a multi-headed scope, thus filling a knowledge gap that is not covered by didactic lectures or textbooks.

This course is a collaboration between the Hans Popper Hepatopathology Society and USCAP.

Learning Objectives

• Recognize hepatitic, lobular, biliary and vascular patterns of liver injury, and use histological clues and clinical data to formulate a meaningful diagnosis.
• Diagnose hepatocellular, biliary and mesenchymal liver tumors, and differentiate between benign and malignant lesions as well as their mimics.
• Diagnose common post-transplant pathologies in allograft biopsies.
• Recognize subtle histological findings in liver biopsies that appear to be near normal.

Course Description

Based on our cumulative experience of encountering problematic genitourinary pathology cases and questions posed by other pathology colleagues over our careers, there is consistent theme of problematic tumors/lesions submitting for formal consultation/second opinion. Here, we aim to offer a “crash-course” groundwork of how we handle such consultation cases, particularly relevant to those who are not as up-to-date with current issues in diagnostic terminology and relevance to clinical management.

Learning Objectives

• Recognize common diagnostic pitfalls and potential sources of interpretive error in kidney, bladder, prostate, penile, and adrenal pathology.
• Appreciate subtle histologic clues to resolve key differential diagnoses in kidney, bladder, prostate, penis, and adrenal cancer specimens.
• Learn when and how to integrate clinical findings and ancillary tests with key cytomorphologic features in precise cytologic diagnosis of lesions from these sites.
• Understand clinically relevant staging parameters and develop diagnostic thresholds for pathologic staging of kidney, bladder, prostate, and penis, and adrenal cancer resections.

Course Description

This course provides a comprehensive overview of breast pathology across the diagnostic spectrum, covering benign, in situ, and malignant lesions encountered in surgical specimens and core needle biopsies. Participants will explore key diagnostic criteria and clinical significance, address common and challenging differential diagnoses, and examine the appropriate use, strengths, and limitations of ancillary immunohistochemical and molecular testing. The course also reviews current prognostic and predictive assays used in the management of patients with breast cancer, with an emphasis on their practical application in clinical practice. This course features lectures, interactive microscopy slide-review, digital slide review with ARS, Q&A, and a panel hot topics session.

Learning Objectives

• Evaluate the diagnostic criteria and clinical significance of various benign, in situ and malignant breast lesions and determine appropriate diagnostic testing.
• Summarize the uses and limitations of techniques such as core needle biopsy and immunohistochemistry.
• Review the role and the limitations of prognostic marker studies in patients with breast cancer Analyze the role of molecular biology and the immune microenvironment in the study of breast diseases.
• Describe differential diagnostic problems commonly encountered in breast pathology and develop strategies to resolve them in your practice environment.
• Determine the importance of pathologic-radiologic correlation in the assessment of non-palpable breast lesions.
• Utilize the latest information on evaluation and reporting of breast lumpectomy margins and evaluation of specimens from patients treated with neoadjuvant chemotherapy.
• Recognize the existence of borderline lesions that are better classified as such on initial core needle biopsy samples.

Course Description

A practical approach to recognizing and reporting clinically relevant alterations of the placenta in a general pathologist practice setting is the main focus of this course, with an additional focus on gestational trophoblastic disease. The course is organized using the 2014 Amsterdam Placental Workshop Group classifications (e.g. maternal vascular lesions, fetal vascular lesions, inflammatory lesions). We will emphasize pattern-based morphology of placental disease; correlation with clinical history and gross pathology; and creation of clinically-relevant pathology reports. The cases presented will include common alterations of clinical significance as well as newer topics including COVID-related pathology and the new FIGO grading system for placenta accreta spectrum. The gestational trophoblastic cases will highlight strategies for recognizing products of conceptions with features suspicious for molar pregnancy and the selection and interpretation of relevant confirmatory diagnostic tests. The target audience is general pathologists and trainees.

Learning Objectives

• Apply the 2014 Amsterdam Placental Workshop Group classifications to evaluation and reporting of placental pathology.
• Identify and report placental alterations that are critical values to patient care or triggers for additional workup of the baby and mother.
• Recognize the morphologic indications of concern for gestational trophoblastic disease and select and interpret appropriate confirmatory diagnostic tests.

Course Description

Thyroid nodules are a common finding in the daily practice of cytology and histopathology, including challenges discriminating benign versus malignant thyroid lesions. Join expert surgical, cyto, and molecular pathologists as they navigate the complexities of the thyroid gland. This course will analyze and summarize the changes in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors, with specific focus on follicular-derived neoplasms. Faculty will also evaluate the recent changes in the third edition of The Bethesda System for Reporting Thyroid Cytopathology focusing on the indeterminate and suspicious for malignancy categories. While most thyroid neoplasms are epithelial, this course will also dive into mesenchymal lesions of the thyroid gland, especially as they enter the differential of spindle cell or hybrid spindle-epithelioid lesions of thyroid gland and neck. The molecular underpinnings of thyroid diseases will be emphasized, especially as they relate to diagnostic classification and prognosis. Faculty will walk attendees through simple and complex cases and discuss differential diagnoses. Join us on this exciting journey into the secrets of thyroid gland, in a course exploring a broad range of diagnoses that may be encountered in daily practice.

Learning Objectives

• Recognize the key diagnostic features for the thyroid lesions on histology and cytology.
• Recognize key thyroid tumor subtypes with distinctive molecular profiles and clinical behaviors.
• Develop an algorithmic approach to key categories in evaluation of thyroid lesions on histology and cytology.
• Recognize the key diagnostic features for non-epithelial thyroid lesions.

Course Description

This course provides an in-depth, case-based approach to the diagnosis of challenging lymphoid and plasma cell disorders, with emphasis on entities that feature diffuse lymphohistiocytic backgrounds, prominent plasma cell components, and complex bone marrow involvement. Through integrated morphologic, immunophenotypic, molecular, and clinical correlation, participants will develop practical strategies to distinguish neoplastic processes from their reactive mimics and to recognize unexpected or composite pathologies.

Learning Objectives

Upon completion of this educational activity, the learner will be able to:

• Recognize and characterize lymphomas and reactive conditions that present with a diffuse lymphohistiocytic background, integrating morphologic, immunophenotypic, and clinical features.
• Differentiate reactive B, T, and plasma cell disorders from neoplasms in the bone marrow, with emphasis on clinically significant mimics and pitfalls.
• Apply a systematic diagnostic approach to amyloidosis in lymph nodes, lung, and bone marrow, including recognition of associated lymphoproliferative and plasma cell neoplasms.
• Identify and appropriately interpret unexpected findings in bone marrow pathology that have important diagnostic, prognostic, or therapeutic implications.

Course Description

The Arthur Purdy Stout Society of Surgical Pathologists (APSS) and USCAP continue their collaborative commitment to providing superb education for practicing pathologists. The Eighth Edition of Modern Surgical Pathology Through the Expert Eyes of APSS-USCAP is designed to eliminate a variety of practice gaps in diagnostic surgical pathology. The faculty’s review of the literature and collective clinical experience as consultant surgical pathologists have revealed areas that remain problematic for pathologists. Examples include the evaluation for invasion in biopsies of the genitourinary tract, the distinction of benign processes from intraepithelial neoplasia in the breast, the classification of inflammatory conditions of the gastrointestinal tract, and the differential diagnoses of problematic gynecologic and soft tissue tumors.
This course attempts to help pathologists eliminate diagnostic errors by highlighting pitfalls and providing approaches to resolve them using routine microscopic examination and immunohistochemistry. The role of adjunctive molecular tests will be discussed as appropriate. The course is designed to address both molecular tests and medical knowledge and competence with the goal of improving clinical practice.
Registrants will have the opportunity to experience USCAP’s international headquarters and learning center at the heart of vibrant Palm Springs, California, a unique and fascinating resort destination.
This course is a collaboration between the Arthur Purdy Stout Society of Surgical Pathologists (APSS) and USCAP.

Learning Objectives

• Eliminate diagnostic errors by recognizing typical pitfalls and utilizing provided approaches to resolving these pitfalls in surgical pathology using both routine microscopic examination of H&E-stained sections and ancillary studies.
• Discuss the uses and limitations of immunohistochemistry in diagnostic surgical pathology.
• Discuss the role of newer adjunctive molecular tests where appropriate.
• Address both medical knowledge and competence with the goal of improving clinical practice.

Course Description

Embark on an in-depth exploration of the complex and evolving field of pancreatobiliary pathology through this comprehensive interactive microscopy course. Developed in collaboration with the Pancreatobiliary Pathology Society, this program provides a practical and contemporary approach to the diagnosis of challenging cytologic and surgical specimens from the pancreas and biliary tract.
From foundational principles to advanced diagnostic techniques—including gross examination and frozen section interpretation—this course is designed to enhance diagnostic accuracy and confidence. Anatomic pathology trainees, cytopathologists, and practicing surgical pathologists who routinely encounter these complex specimens are invited to participate and advance their expertise in pancreatobiliary pathology.
This course is a collaboration between the Pancreatobiliary Pathology Society (PbPath) and USCAP.

Learning Objectives

Upon completion of this educational activity, participants will be able to:

• Recognize and interpret the cytologic and histomorphologic spectrum of cystic and solid pancreatic lesions.
• Apply updated terminology, classification systems, and management guidelines for neoplastic mucinous and non-mucinous intraductal pancreatic lesions, including IPMN, MCN, IOPN, and ITPN.
• Review the role and the limitations of prognostic marker studies in patients with breast cancer Analyze the role of molecular biology and the immune microenvironment in the study of breast diseases.
• Utilize updated grading criteria and ancillary studies to accurately classify pancreatic neuroendocrine neoplasms, including classical, grade-discordant, and ambiguous entities.
• Identify and diagnose neoplastic and inflammatory biliary tract lesions, including flat and tumoral intraepithelial neoplasms, and appropriately evaluate limited biopsy and cytology specimens.

Course Description

GI Pathology Essentials: Where We Are Now and Where We Are Headed is an advanced course for pathologists, fellows, and residents aiming to deepen their expertise in gastrointestinal pathology and stay current with evolving diagnostic approaches. Led by faculty with recognized expertise in the field, the course covers drug-induced gastrointestinal injury, autoimmune and inflammatory disorders of the GI tract, mesenchymal tumors, infectious and systemic GI disorders, and unusual polyps/polyposis or molecularly defined neoplasms.
This course emphasizes practical application, combining recent molecular insights and evolving diagnostic strategies to support excellence in both academic and private practice settings.
This course is a collaboration between the Rodger C. Haggitt Gastrointestinal Pathology Society (GIPS) and USCAP.

Learning Objectives

Upon completion of this educational activity, the learner will be able to:

• Apply current and evolving diagnostic criteria to enhance accuracy and consistency in evaluating drug-induced gastrointestinal injury and autoimmune or inflammatory disorders of the GI tract.
• Integrate histologic, immunophenotypic, and emerging molecular findings to classify and diagnose mesenchymal tumors of the GI tract.
• Recognize key histologic patterns and apply appropriate ancillary studies to accurately diagnose infectious and systemic diseases affecting the GI tract.
• Evaluate uncommon and molecularly defined GI polyps/polyposis and neoplasms using integrated morphologic and molecular approaches to enhance diagnostic precision and clinical relevance.

Course Description

This course is designed as a collaboration between USCAP and the Genitourinary Pathology Society (GUPS) with a multifaceted comprehensive approach to various genitourinary (GU) lesions. Four GUPS experts who have joint practice in other pathology areas including endocrine pathology, renal medical pathology, bone and soft tissue pathology, and cytopathology, will present a large variety of non-neoplastic and tumor entities. They will discuss 72 index cases in the most practical way highlighting histogenesis, cellular morphology, architectural patterns, immunohistochemical details and relevant molecular concepts.

A unique and novel feature of this course is an integrated view to GU pathology with input from other subspecialties, thus fostering conceptual thinking, diagnostic correlations and improving overall understanding of GU tract diseases with organ site specific or more generalizable presentations.

Additionally, GUPS experts will share their knowledge of novel entities, up-to-date classification, nomenclature, diagnostic criteria, and current reporting recommendations by professional societies.

This course is a collaboration between the Genitourinary Pathology Society (GUPS) and USCAP.

Learning Objectives

• Recognize, correctly diagnose and report most common lesions and neoplasms involving adrenal gland.
• Understand wide spectrum of renal neoplasia arising from different parts of nephron and discuss how histogenesis correlates with tumor morphology, immunoprofile and molecular changes.
• Identify renal medical diseases frequently found in background kidney parenchyma and their clinical implications.
• Become familiar with common, rare and unique to GU tract soft tissue tumors.
• Navigate morphologic features of GU inflammatory and neoplastic entities by cytologic-histologic comparisons.

Course Description

Join USCAP in Singapore for the Best of Diagnostic Pathology Update! These repeat presentations from the 2026 course will deliver cutting-edge insights across various pathology subspecialties, emphasizing pragmatic approaches for daily practice. This program convenes distinguished faculty to lead you through lectures and case-based presentations. Topics included are genitourinary, breast, dermatopathology, gynecologic, and gastrointestinal.

Course Description

Soft tissue tumors may arise in visceral organs, where they can mimic more common site-specific neoplasms such as carcinomas. In addition, certain mesenchymal tumors demonstrate a predilection for particular organ systems. This course will highlight characteristic soft tissue tumors of visceral sites, including the thorax, breast, skin, the gastrointestinal, and gynecologic tracts. Participants will gain practical tools to distinguish mesenchymal tumors from their epithelial mimics through expert-led instruction from leaders in the field.

Learning Objectives

• Review the morphology of a comprehensive set of benign and malignant soft tissue tumors.
• Recognize key features of common benign entities to avoid misclassification as malignant.
• Recognize common mimics of sarcomas including sarcomatoid carcinoma and transdifferentiated melanoma.
• Understand the rationale for molecular testing in soft tissue tumors.

Course Description

Join expert pathologists as they provide essential hints and tips for navigating challenging cases in surgical pathology. The selected cases will cover a variety of conditions commonly encountered in daily practice. Additionally, the faculty will share insights on nomenclature, classification, staging, histological, immunohistochemical features, and the potential applications of molecular techniques. The specialties discussed will include breast, bone and soft tissue, thoracic, genitourinary, gastrointestinal, and gynecological pathology. Discussions will focus on case-based presentations.

Learning Objectives

• Provide current nomenclature of different tumors by organ system.
• Provide current information of new immunohistochemical stains that may aid in the diagnosis.
• Provide current staging systems in tumor pathology.
• Provide current information of the role of molecular diagnostics.
• Share experiences with difficult and controversial cases.

Course Description

In this interactive microscopic course, the participants will interact with six dedicated and experienced cardiovascular pathologists, discussing some common but easily missed cardiovascular disease entities. From valvular disease to vasculitis, from sudden cardiac death to amyloidosis, the participants will have the opportunity to integrate gross examination, microscopic findings, imaging correlation, ancillary testing, and clinical information to reach the correct diagnosis.

Four major fields in cardiovascular pathology will be covered in this course, including cardiac tumor, myocardial diseases, valvular diseases and vascular diseases. By the end of the course, the participants will gain knowledge and diagnostic skill in a wide range of cardiovascular diseases.

This course is a collaboration between the Society for Cardiovascular Pathology (SCVP) and USCAP.

Learning Objectives

• Identify histological features and understand the diagnostic criteria of common and uncommon cardiovascular diseases.
• Correlate genetic testing, imaging findings, gross examination, and microscopic findings for cardiovascular diseases.
• Recognize overlapping and distinct features of varies entities in differential diagnoses and undertake additional workup to render an accurate diagnosis.

Course Description

Gynecologic pathology practice is constantly evolving. Between the new version of the WHO Blue Book, ever changing staging systems, new molecular assays and immunostains, pathologists are often awash in a deluge of new information. Six expert academic pathologists will provide a practical, approachable, concise overview of the current landscape of gynecologic pathology and provide practice tips that will be beneficial in your daily practice.

Two formats will be utilized:

• Slide seminars with dedicated time for review of histological material by each participant at the microscope, followed by discussion of each case with the faculty in the multi-headed microscope.
• Roundtable discussions, in which the faculty give their perspective on new, emerging and controversial issues in gynecologic practice, with opportunities to ask questions and practical advice.

Learning Objectives

• Understand and apply in daily practice essential resources, including the upcoming WHO classification of tumours of the female reproductive system, the most recent updates to the FIGO staging systems, ICCR resources, and current NCCN guidelines for the management of patients with gynecologic cancer.
• Appraise emerging information on clinically relevant forms of endometrial, upper genital and mesenchymal gynecologic neoplasia.
• Describe the novel classification systems for lower genital tract neoplasia including the currently recommended nomenclature.
• Identify the scenarios in which diagnosis of non-epithelial (mesenchymal, sex-cord stromal, gestational) gynecologic neoplasia, as per WHO criteria, requires molecular testing as an essential criterion, and how to proceed when such testing is not available.
• Discuss the role of biomarker testing in the diagnosis, prognosis and management of patients with ovarian cancer, endometrial cancer and cervical cancer.

Course Description

Pathologists who evaluate specimens from the gastrointestinal tract occupy an expanding role in disease management teams. The widespread availability of endoscopy coupled with advances in tissue acquisition techniques have drastically increased the number and variety of gastrointestinal samples pathologists encounter in daily practice. As a result, pathologists are now required to provide comprehensive diagnostic information based on review of scant material. Classification of tumors is often completed based on interpretation of immunohistochemical stains coupled with molecular analyses to identify druggable targets or underlying germline conditions. Pathologists also direct the evaluation of patients with gastrointestinal complaints, particularly when patients have persistent symptoms or are immunosuppressed. Thus, they must be able to hone in on key features present in biopsy material in order to narrow the differential diagnosis and better direct patient care. This course is intended to address these needs in a succinct and pragmatic fashion.

Course Description

Join USCAP in Edinburgh, Scotland, for the 2027 Diagnostic Pathology Update, where you will experience expert-led education and a vibrant destination. This program convenes distinguished faculty to deliver cutting-edge insights across various pathology subspecialties, emphasizing pragmatic approaches for daily practice. Immerse yourself in an intimate setting ideal for collaboration and networking with peers and luminaries in your field.

Course Description

This dynamic, interactive microscopy course is designed to help participants stay current in the rapidly evolving field of dermatopathology. Through real-world cases and hands-on microscopy, participants will learn the latest cutaneous tumor classification, novel diagnostic entities, and the appropriate use of ancillary testing. Case-based discussions will also address common diagnostic challenges in neoplastic and inflammatory skin diseases, with an emphasis on recognizing key histopathologic clues and applying practical strategies (“life hacks”) at the microscope. It is intended for dermatopathologists, surgical pathologists, and pathology trainees seeking to sharpen their diagnostic skills in dermatopathology.

Learning Objectives

Upon completion of this educational activity, the learner will be able to:

• Identify unique histomorphologic features and genetic aberrations in melanocytic, mesenchymal, and hematolymphoid skin neoplasms.
• Predict underlying molecular changes in specific skin tumors by paying close attention to histomorphologic clues.
• Diagnose rare and newly emerging inflammatory dermatoses by integrating histopathologic findings and clinical data.
• Discuss the optimal use and limitations of ancillary studies in dermatopathology.

Course Description

In pathology practice, every busy day on service presents a diverse array of cases. While many are routine, they often conceal subtle yet significant pitfalls. Others represent genuinely difficult and challenging diagnoses. In addition, new developments — including emerging diagnostic entities, updated grading and staging criteria, novel diagnostic tools, and evolving reporting requirements — continuously enter routine practice.
This course is designed to simulate these real-world diagnostic challenges. Expert faculty in gastrointestinal, urological, and cytopathology will guide participants through a curated selection of interesting and difficult cases. The session will focus on efficiently signing out routine cases while avoiding common pitfalls, applying essential diagnostic algorithms, and integrating the latest updates and best practices in the field. Cytology plays a critical complementary role, particularly in urinary tract evaluation (Paris System) and pancreatobiliary sampling (WHO Reporting System) and is often the first, or only opportunity for early diagnosis.

Learning Objectives

• Apply updated WHO classifications, grading systems, staging criteria, and standardized reporting frameworks in GI, liver, GU, and cytopathology cases.
• Differentiate benign mimics, treatment-related changes, and reactive processes from Differentiate benign mimics, treatment-related changes, and reactive processes from malignancy using morphology and focused ancillary testing in GI, GU, and cytopathology.
• Integrate histologic, cytologic, immunohistochemical, molecular, and clinical findings to accurately classify challenging primary and metastatic lesions.
• Implement efficient, evidence-based sign-out strategies that improve diagnostic accuracy and reporting consistency in high-volume practice settings.