The lecture will provide an overview of the recent molecular advances that have had a significant impact on the classification, diagnosis and management of soft tissue tumors. A particular emphasis will be given to sarcomas that are characterized by chromosomal translocations, an area of most dramatic and impactful change in the recent decade. The presentation will also draw attention to the evolving role of practicing pathologists during a period of significant changes, demands from medical oncologists and emerging new molecular diagnostic platforms.