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 Alan L. Schiller, M.D., Mount Sinai School of Medicine, New York, NY and Andrew E. Rosenberg, M.D., Harvard Medical School, Boston, MA This course covers practical non-neoplastic orthopaedic pathology. Surgical specimens from patients suffering from garden variety orthopaedic disorders represent some of those most commonly encountered by surgical pathologists, yet are frequently the least understood. The course begins by building a foundation of knowledge based on the normal physiology and histology of bone and joints, which helps provide a framework for the subsequent discussion of the morphology of arthritis, important conditions of the synovium, common crystal deposition diseases, meniscal problems and some congenital abnormalities. Entities such as osteoarthritis, rheumatoid arthritis, osteonecrosis, crystalline diseases (gout, CPPD), Gaucher’s disease, joint mice, synovial chondromatosis, torn and degenerated menisci, pathology of prosthetic joints and pigmented villonodular synovitis, will be discussed. Upon completion of this course, participants should be able to identify basic fundamentals of bone growth and recognize key histologic features needed for diagnosis; define basic mechanisms regarding bone and joint pathology which are unique; and recognize pathophysiology of non-tumorous conditions of bone and joints. This course is designed for residents, fellows and surgical pathologists. The format will vary, but will include case discussion leading to didactic presentation for different pathologic conditions. A CD of representative materials and a handout will be distributed at the course.
Robert D. Odze, M.D., John N. Glickman, M.D., and Mark S. Redston, M.D., Brigham and Women’s Hospital, Boston, MA This course is designed to offer general pathologists, pathologists in training, and pathologists with a particular interest in gastrointestinal pathology, an overview of the pathogenesis, diagnosis, differential diagnosis and management of common metaplastic and dysplastic lesions in the esophagus, stomach, small and large intestine. The course will include an overview of the molecular pathogenesis of these lesions with particular emphasis on the application of molecular biology for prognosis and management issues. Emphasis will be placed on diagnostically challenging and controversial aspects of metaplastic and dysplastic lesions of the gastrointestinal tract and those which have important clinical implications regarding patient management. Some of the topics to be discussed in this course include Barrett’s esophagus and associated dysplasia, metaplasia and dysplasia of the gastroesophageal junction, esophageal squamous dysplasia, gastric intestinal metaplasia and dysplasia [flat and polypoid lesions (fundic gland polyp, hyperplastic polyp, adenoma)], dysplasia in inflammatory bowel disease and dysplasia in sporadic adenomas and in syndromic polyps. A case presentation format will be used as a basis for discussion of these lesions. The role of new techniques, such as immunohistochemistry, flow cytometry, mucin histochemistry, and DNA diagnostics will be discussed wherever appropriate. No materials will be mailed prior to the course. A comprehensive syllabus will be distributed at the course. A CD containing copies of all slides presented during the course, as well as the text handout will bedistributed at the course.
Bruce M. Wenig, M.D., Beth Israel Medical Center, New York, NY and Mary S. Richardson, D.D.S., M.D., Medical College of South Carolina, Charleston, SC This course is designed as a case based analysis of the significant diagnostic and therapeutic issues relative to the intraoperative assessment of selected head and neck lesions. The major categories of lesions to be discussed include: 1) surgical margins; 2) benign simulators of squamous cell carcinoma; 3) skull base lesions; 4) intraoral salivary gland neoplasms; 5) major salivary gland neoplasms; 6) neck masses; 7) thyroid gland neoplasms and 8) parathyroid gland proliferative diseases. Emphasis will be placed on the light microscopic features required for proper interpretation. When applicable, adjunct diagnostic modalities and pertinent clinical information that factor into the intraoperative consultation will be incorporated. The potential utilization of molecular biology in the intraoperative assessment of head and neck squamous cell carcinoma (“molecular margins”) will be discussed. The course will serve as a practical guide for pathologists at all levels of training and practice. All registrants will receive a CD with images and a detailed syllabus at the course.
A. Neil Crowson, M.D., University of Oklahoma and Regional Medical Laboratories, Tulsa, OK, Cynthia M. Magro, M.D., Weill Medical College of Cornell University, New York, NY, and Martin C. Mihm, Jr., M.D., Massachusetts General Hospital and Harvard Medical School, Boston, MA This course is designed for pathologists-in-training, dermatologists with an interest in dermatopathology and surgical pathologists who encounter in their daily practice problematic melanocytic neoplasms. Ten representative lesions will be presented in case format. The intention is to focus upon the common precursors to malignant melanoma, melanoma mimics, and the controversial malignant neoplasms of melanocytic lineage. Each case will be used as a springboard for the discussion of the differential diagnosis of a different form of melanocytic lesion. In addition to a heavy emphasis upon conventional light microscopic criteria for diagnosis, the authors will expand, where appropriate, on recent advances in the pathophysiology of melanocytic neoplasia. The categories of melanocytic lesions discussed will include: 1) melanoses, 2) dermal melanocytoses, 3) dysplastic and common acquired nevi, 4) congenital nevi, 5) combined nevi, 6) Spitz’s nevi and the atypical Spitz tumor, 7) malignant melanoma with an emphasis on unusual variants including myxoid melanoma, malignant blue nevus, nevoid melanoma, melanoma with prominent pigment synthesis, minimal deviation and borderline tumors, 8) how to report a malignant melanoma, and 9) how to report the prognostically equivocal melanocytic proliferation. In the course of the discussion of the above categories, the course directors will elaborate upon the pathophysiologic bases of familial dysplastic nevus syndrome and the malignant transformation of melanocytic proliferations and their histomorphological expression in the skin. Registrants will receive a CD with images and a comprehensive syllabus at the course.
Rana S. Hoda, M.D., FIAC, Medical University of South Carolina, Charleston, SC Syed A. Hoda, M.D., New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY This course is intended to provide a comprehensive overview of The Pap Test (cervicovaginal cytopathological examination). The intended audience includes pathologists wishing to refresh and update their knowledge of this test, fellows and residents. The emphasis will be on basic and practical matters. First, the relevant anatomical aspects and preparatory aspects of The Pap Test will be discussed. Second, the principles outlined in The Bethesda System will be presented. Third, the spectrum of findings in this test will be reviewed. Fourth, the cytological and clinical aspects of common lesions encountered in the test will be described using eight illustrative cases. Evolving developments in technique (including liquid-based preparations and HPV-testing) and emerging regulatory (including quality assurance) facets will be reiterated at appropriate points. At intervals, the participants’ insights and inquiries will be welcomed. A CD-ROM containing 50+ classical entities encountered in The Pap Test with accompanying legends will be provided. A complete syllabus as well as a print-out of the entire PowerPoint based course material will be distributed at the course. Upon completion of the course, the participants will be expected to develop an enhanced understanding of current cytological criteria and changing clinical concepts regarding The Pap Test.
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