—  SPECIALTY CONFERENCE  — Dermatopathology Monday, February 28, 2011, 7:30 PM CC 001 A/B Challenging Skin Tumors: Recognition and Recommendation Moderator: STEVEN R. TAHAN Beth Israel Deaconess Medical Center, Boston, MA Disclosure: In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Symposium) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. The speakers listed below have indicated they have nothing to disclose. Panelists: Rajiv M. Patel, University of Michigan Health System, Ann Arbor, MI Alireza Sepehr, Beth Israel Deaconess Medical Center, Boston, MA Thomas Brenn, Western General Hospital and The University of Edinburgh, Edinburgh S. David Hudnall, Yale University School of Medicine, New Haven, CT David E. Elder, Hospital of The University of Pennsylvania, Philadelphia, PA Clinical histories are displayed below. For the fastest viewing of virtual slides, click: under each thumbnail image below. You must have Aperio ImageScope installed on your PC. If you do not already have Aperio ImageScope, Windows users with administrator privileges may download and install a free version in order to view USCAP Virtual Slides. Click the icon on the right to get your free copy:   Or, click on slide thumbnail images to view each slide in a Web-based slide viewer, which is somewhat slower. If you have any difficulties viewing these slides, email or call George Clay at +1.724.449.1137. Case 1 Submitted by: Rajiv M. Patel - Clinical Summary: 29-year-old male with a 5-year history of a slow-growing nodule on the plantar aspect of the base of the first toe overlying the first metatarsal phalangeal joint. The lesion was excised by the patient's podiatrist. Case 1 - Slide 1 Click to view with ImageScope Click to view with a Web-Based Viewer Case 1 - Figure 1 Case 1 - Figure 2 Case 1 - Figure 3 Case 1 - Figure 4 Case 1 - Figure 5 Case 1 - Figure 6 Case 1 - Figure 7 Case 1 - Figure 8 S-100 Case 1 - Figure 9 HMB45 Case 1 - Figure 10 MITF Case 2 Submitted by: Alireza Sepehr - Clinical History: A 32-year-old man presented with a mass on his left index finger in 1993. A biopsy was performed. Pertinent Laboratory Data: In gross pathologic examination, the specimen consisted of gray to tan-pink nodular fragments of soft tissue and measured 3.0 x 1.0 x 0.5 cm in aggregate. The cut surface revealed a multilocular appearance with semi-viscous fluid contents. Case 2 - Figure 1 Case 2 - Figure 2 Case 2 - Figure 3 Case 2 - Figure 4 Case 2 - Figure 5 Case 2 - Figure 6 Case 2 - Figure 7 Case 3 Submitted by: Thomas Brenn - Clinical Summary: A 79 year old female presents with three recently developed skin lesions in the right axilla (two biopsies are shown below). The patient has a past medical history of invasive breast carcinoma treated with mastectomy, axillary lymph node clearance and adjuvant radiation in 2004. Case 3 - Figure 1 Case 3 - Figure 2 Case 3 - Figure 3 Case 3 - Figure 4 CD31 Case 3 - Figure 5 Case 3 - Figure 6 Case 3 - Figure 7 CD31 Case 3 - Figure 8 CD31 Case 4 Submitted by: S. David Hudnall - Clinical Summary: 9 year old afebrile boy presents with skin lesions of the upper extremities and face along with generalized lymphadenopathy. Pertinent Laboratory Data: CBC reveals pancytopenia. Biopsy of subcutaneous tissue from arm is obtained. Case 4 - Figure 1 Case 5 Submitted by: David E. Elder - Clinical Summary: A 9 year old child presented with a nodular lesion of the back. The lesion had appeared suddenly and grown rapidly over several weeks, more recently developing a crust and occasionally bleeding. A fragment of skin was received, with a central ulcerated nodule. Case 5 - Figure 1 Case 5 - Figure 2 Case 5 - Figure 3 Case 5 - Figure 4 Case 5 - Figure 5 Case 5 - Figure 6 Case 5 - Figure 7 Case 5 - Figure 8 Case 5 - Figure 9 Handouts for all Specialty Conferences will be accessible via the "Educational Materials" section on the homepage the morning after each respective conference. Printed copies of the handout will not be available at the meeting.