COMPANION MEETINGS Renal Pathology Society   Sunday, February 27, 2011 — 8:30 a.m., CC 006 A-D   IgG4 in Systemic Disease and the Kidney   Moderators: Carrie Phillips, Indiana University, Indianapolis, IN and Megan Troxell, Oregon Health & Science University, Portland, OR   Disclosure: In accordance with ACCME guidelines regarding disclosure, the USCAP policy requires that faculty members who have a significant financial or other relationship with a commercial company, entity, or service (which will be discussed in this Symposium) must disclose this to attendees. The Academy also requires that speakers disclose any products that are not labeled for the use under discussion. The speakers listed below have indicated they have nothing to disclose. Click the button above to add this event to your Itinerary Planner... 8:30 Introduction to the Immune System and Potential Sources of Dysregulation - Thomas Fleisher, National Institutes of Health, Bethesda, MD 9:15 IgG4 Systemic Sclerosing Disease and Retroperitoneal Fibrosis - Tom Smyrk, Mayo Clinic, Rochester, MN 10:00 Break 10:30 IgG4-Associated Interstitial Nephritis - Lynn Cornell, Mayo Clinic, Rochester, MN 11:15 Anti-PLA2R IgG4: Is It More Than A Marker of Primary Membranous Nephropathy? - David Salant, Boston University, Boston, MA This program was proposed by the Renal Pathology Society (RPS) Program Committee, and approved by the RPS Board of Directors. lgG4 has unique physiochemical properties and has an important and recently characterized association with a spectrum of immune-related diseases of the kidney and other organ systems. The objectives of this symposium are to provide a background in basic pathophysiology of lgG4 and mechanisms of autoimmunity, and to explore the pathology of lgG4 in systemic sclerosing diseases, including pancreatitis, sclerosing mesenteritis, retroperitoneal fibrosis and lgG4 associated interstitial nephritis. The recently elucidated role of lgG4 and antibodies to PLA2R in membranous nephropathy will be discussed. This program is designed to synthesize current knowledge on lgG4 associated conditions for both surgical and renal pathologists.